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Tuesday, June 28 • 2:30pm - 3:30pm
IMGTStatClonotype: An R package with integrated web tool for pairwise evaluation and visualization of IMGT clonotype diversity and expression from IMGT/HighV-QUEST output

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Poster #11

The adaptive immune response is our ability to produce up to 2.10$^{12}$ different immunoglobulins (IG) or antibodies and T cell receptors (TR) per individual to fight pathogens. IMGT$^$, the international ImMunoGeneTics information system$^$ (http://www.imgt.org), was created in 1989 by Marie-Paule Lefranc (Montpellier University and CNRS) to manage the huge and complex diversity of these antigen receptors and is at the origin of immunoinformatics, a science at the interface between immunogenetics and bioinformatics. Next generation sequencing (NGS) generates millions of IG and TR nucleotide sequences, and there is a need for standardized analysis and statistical procedures in order to compare immune repertoires. IMGT/HighV-QUEST is the unique web portal for the analysis of IG and TR high throughput sequences. Its standardized statistical outputs include the characterization and comparison of the clonotype diversity in up to one million sequences. IMGT$^$ has recently defined a procedure for evaluating statistical significance of pairwise comparisons between differences in proportions of IMGT clonotype diversity and expression, per gene of a given IG or TR V, D or J group. The procedure is generic and suitable for detecting significant changes in IG and TR immunoprofiles in protective (vaccination, cancers and infections) or pathogenic (autoimmunity and lymphoproliferative disorders) immune responses. In this talk, I will present the new R package (’IMGTStatClonotype’) which incorporates the IMGT/StatClonotype tool developed by IMGT$^$ to perform pairwise comparisons of sets from IMGT/HighV-QUEST output through a user-friendly web interface in users’ own browser.

avatar for Safa  Aouinti

Safa Aouinti

IMGT® - the international ImMunoGeneTics information system®, Institute of Human Genetics

Tuesday June 28, 2016 2:30pm - 3:30pm PDT
Sponsor Pavilion

Attendees (6)